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News - Male Aging and Hormones

Articles and Reports - Table of Contents
Links to Original Articles and Reports

Testosterone Misconceptions

It is hard to go a day without seeing or hearing an advertisement for an erectile dysfunction drug or a fix for "Low-T". While the media are obsessed with these two issues, other sexual problems are quite common and unrelated. Most sexual dysfunction, especially orgasm problems are due to hormone imbalances that can easily be corrected using natural substances.

Testosterone replacement therapy may benefit male cancer survivors with testosterone deficiency.

A new study has found that many male cancer survivors who develop testosterone deficiency after receiving chemotherapy or radiation therapy have an impaired quality of life and reduced energy levels. Published early online in Cancer, a peer-reviewed journal of the American Cancer Society, the study suggests that young male cancer survivors with testosterone deficiency may benefit from testosterone replacement therapy.

A Guide to Natural Hormone Balancing for Men
By James Occhiogrosso, N.D., Posted March 21, 2009

When an aging man first encounters a problem with his sexuality, it is almost inevitable that his thoughts turn to testosterone. In many men, low testosterone levels cause significant problems, not only with sexuality, but also by setting the stage for some serious health issues. But testosterone is only one player in this complicated orchestra.

A Guide to Testosterone Supplementation for Older Men
By James Occhiogrosso, N.D., Posted May 4, 2008

Testosterone is an extremely important hormone for the overall health of the human body and particularly critical for male sexual ability, libido, and satisfaction. Recent studies have shown testosterone deficiency contributes to reduced muscle mass, reduced bone mass, male breast enlargement, depression, atherosclerosis, increased risk of development of Alzheimer’s disease, anemia, and diabetes, and increased overall mortality from all causes. Using an herbal supplement to support your body in producting more testesterone can be very rewarding, especially if your levels are low. This article tells you how. 

Testosterone replacement therapy for senior men beneficial
Men's Health News, Published: Tuesday, 8-Apr-2008

The risk of osteoporosis (bone fracture) in women is highly recognized by the public. Less appreciated is the fact that the disorder also occurs in men. Some two million males have been diagnosed with osteoporosis and another three million are at risk. Gender-based hormones and age are thought to be major factors behind bone fractures in both sexes.

Low testosterone levels linked to depression in older men
Men's Health News, Published: Tuesday, 4-Mar-2008

Older men with lower free testosterone levels in their blood appear to have higher prevalence of depression, according to a report in the March issue of Archives of General Psychiatry.

Low Free Testosterone Concentration as a Potentially Treatable Cause of Depressive Symptoms in Older Men
Osvaldo P. Almeida, et al, Archives of General Psychiatry, Vol. 65, No. 3:283-289, March 2008

This study of 3987 men found that men with depression were  one-and-one-half times more likely to have low total testosterone levels and nearly three times more likely to have a low free testosterone level.

Low Serum Testosterone and Mortality in Older Men
Gail A. Laughlin, et el, Journal of Clinical Endocrinology & Metabolism, Vol. 93, No. 1:68-75, Jan 2008

Testosterone insufficiency in older men is associated with increased risk of death over the following 20 year period, independent of multiple risk factors and several preexisting health conditions.

Endogenous Testosterone and Mortality Due to All Causes, Cardiovascular Disease, and Cancer in Men
Kay-Tee Khaw, et al, Circulation. Vol. 116:2694-2701, Nov. 2007

Testosterone concentrations in men are inversely related to mortality due to cardiovascular disease and all causes. Low testosterone may be a predictive marker for those at high risk of cardiovascular disease.

Estrogen, Not Testosterone, Levels Differ Between Black and White Men
Reuters Health, Aug. 23, 2007, by Martha Kerr

Black men have higher serum estradiol levels than white men, and both have higher levels than Mexican-American men, researchers report. Contrary to the "postulated racial difference," they found, testosterone concentrations did not differ between black and white men.

Low levels of testosterone may increase the long-term risk of death in men over 50 years old
Men's Health News, Published: Tuesday, 12-Jun-2007

Low levels of testosterone may increase the long-term risk of death in men over 50 years old, according to researchers with the Department of Family and Preventive Medicine at the University of California, San Diego School of Medicine.

Testosterone and Ageing: What Have We Learned Since the Institute of Medicine Report and What Lies Ahead?
Medscape.com — M. M. Miner, A. D. Seftel, Int J Clin Pract. 61(4):622-632, Posted 05/21/2007

A 2003 report by the Institute of Medicine (IOM) surveyed the literature on the benefits and risks of testosterone replacement therapy in older men and identified knowledge gaps and research needs. This review summarizes some key studies published since the IOM report. The possible relationship of testosterone to risk of prostate cancer remains a concern; however, no new evidence has emerged to suggest that testosterone replacement therapy increases the risk. Recent studies have demonstrated that hypogonadism in men may be more prevalent than previously thought, is strongly associated with metabolic syndrome, and may be a risk factor for type 2 diabetes and cardiovascular disease. Clinical studies have shown that testosterone replacement therapy in hypogonadal men improves metabolic syndrome indicators and cardiovascular risk factors. Maintaining testosterone concentrations in the normal range has been shown to contribute to bone health, lean muscle mass, and physical and sexual function, suggesting that testosterone replacement therapy may help to prevent frailty in older men. Based on current knowledge, testosterone replacement therapy is unlikely to pose major health risks in patients without prostate cancer and may offer substantial health benefits. Larger, longer-term randomised studies are needed to fully establish the effects of testosterone replacement therapy.

Testosterone May Be Neuroprotective for Men With MS
Medscape Medical News May 17, 2007 By: Susan Jeffrey

A small exploratory trial shows that treatment with testosterone gel was safe and well tolerated by men with relapsing remitting multiple sclerosis (RRMS) and was associated with some improvement in cognitive performance and slowing of brain atrophy over a 1-year period. However there was no effect on gadolinium-enhancing lesion numbers or volume on magnetic resonance imaging (MRI). The results are published in the May issue of the Archives of Neurology.
"Overall, in this first trial of testosterone treatment in men with RRMS, the treatment was shown to be safe and well-tolerated and led to increases in lean body mass," the researchers, with first author Nancy L. Sicotte, MD, from the David Geffen School of Medicine at the University of California, Los Angeles, conclude. "In addition, exploratory findings reported herein suggest a possible neuroprotective effect of testosterone treatment in men, which warrants further investigation."

Low serum testosterone levels independently associated with fall risk in elderly men
Men's Health News, Published Sunday, 15-Apr-2007

Prolonged hypogonadism may result in erectile dysfunction, decreased libido, anemia, sarcopenia, memory loss, bone mineral loss, and the metabolic syndrome. While a low serum testosterone level is well-known for its association with osteoporosis, the impact of hypogonadism on overall physical functioning and fall risk has not been prospectively evaluated.

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Total sleep time affects morning testosterone levels
Men's Health News, Published Monday, 2-Apr-2007

The testosterone levels of healthy men decline as they get older. As sleep quality and quantity typically decrease with age, objectively measured differences in the amount of sleep a healthy older man gets can affect his level of testosterone in the morning, according to a study published in the April 1st issue of the journal SLEEP.

Low testosterone common in type 2 diabetic men
Reuters Health — Source: Diabetes Care, April 2007.

Men with type 2 diabetes, particularly those who are obese, often have low levels of testosterone, making them susceptible to sexual dysfunction, research indicates.

Androgen deprivation therapy may increase risk of death from heart disease in older men.
From: Men's Health News — Monday, 26-Feb-2007

Androgen deprivation therapy - one of the most common treatments for prostate cancer - may increase the risk of death from heart disease in patients over age 65, according to a new study.

 Obesity, illness speed testosterone decline
Reuters Health — Source: The Journal of Clinical Endocrinology and Metabolism, February 2007.

Gaining too much weight can accelerate the decline in testosterone levels that accompanies aging, a new study shows. "Although hormone declines appear to be an integral aspect of the aging process, rapid declines need not be dismissed as inevitable," the researchers conclude. Men's testosterone levels fall as they get older, which may contribute to health problems such as diabetes, loss of bone and muscle mass, and sexual dysfunction, Dr. Thomas G. Travison of New England Research Institutes in Watertown, Massachusetts and colleagues note in a report in The Journal of Clinical Endocrinology and Metabolism.

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